The causal role of senescence on impaired energy homeostasis is demonstrated by targeting senescent cells with drug‐inducible “suicide” genes driven by the p16(Ink4a; Palmer, Xu, et al., 2019) or p21 (Wang et al., 2022) promoter or by senolytic drugs in obese and aged mice, strategies associated with reduction of age‐ and obesity‐related metabolic abnormalities. The gene discussed is CDKN2A; the disease is Obesity.