The SELE polymorphism results revealed no significant differences in allele or genotype frequencies between BC patients and controls, but it was interesting to note that the heterozygous genotypes at rs5367, rs5368, rs5361, and rs5362 were significantly increased in BC patients, and all heterozygous genotypes accounted for 46.7%, 53.3%, 33.3%, and 43.3%, respectively of BC cases, with positive associations shown by ORs of 5.70, 16.3, 4.50, and 3.80, respectively. Here, SELE is linked to breast cancer.