KRT19 and neoplasm: In addition to worse differentiation, the LR-M category has also been reported to correlate with other aggressive pathomolecular characteristics of HCC, including increased stemness features (i.e., expression of CK19) [19], more pronounced macrotrabecular pattern, more frequent microvascular invasion and sinusoid-like microvascular pattern, and a more hypoxic and fibrotic tumor microenvironment [20].