Macrophage phenotype-switching between the pro-inflammatory M1 and the anti-inflammatory M2 phenotype exhibit plasticity during the post-MI inflammatory response and tissue repair.201 Using a mouse MI model, Tang et al.169 found that the expression of Ncl mRNA and protein decreased gradually from day 3 after MI, then increased gradually, reaching a peak on day 7. The gene discussed is NUCLEOLIN; the disease is myocardial infarction.