TP53 and cancer: Katarzyna and colleagues found that the RNA helicase Ddx21, an important regulator of rRNA synthesis and ribosome biogenesis, controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial ribosome biosynthesis and p53 function.259 This mechanism may be targeted in diseases of hyperlymphangiogenesis, such as cancer metastasis or lymphatic malformations.