NUCLEOLIN and atherosclerosis: It has also been shown that under normal conditions, the interaction between Ncl with Dnm3os prevents its enrichment to histone H3K9ac on the promoters of pro-inflammatory genes such as IL6.193 However, Sun et al.206 showed that oxidized low-density lipoprotein (oxLDL), one of the inducers of atherosclerosis, upregulates Ncl mRNA and protein expression in vascular smooth muscle cells (VSMCs) in a dose-dependent manner.