Current studies confirm that Ncl can protect against MI through myocardial ischemic preconditioning (IP).191 IP is a short period of myocardial ischemia/reperfusion (I/R), significantly reducing the damage caused by subsequent long-term I/R, and is also a powerful endogenous heart protection mechanism.198,199 Jiang et al.200 found that Ncl is an important endogenous cardioprotective factor in myocardial IP. This evidence concerns the gene NUCLEOLIN and myocardial infarction.