The core regulator of the PeBoW complex may be involved in the production of 28S and 5.8S rRNA.177 Jia et al.177,178 found that BOP1 is increased in the coronary arteries of patients with atherosclerosis and is accompanied by the neointimal hyperplasia caused by VSMC proliferation (Fig. 6b). The gene discussed is BOP1; the disease is atherosclerosis.