Researchers found that Ncl combines with noncoding RNA cytoskeleton regulator RNA and then jointly participates in the development of colorectal cancer.245 Ncl also binds to telomerase reverse transcriptase (TERT) in the nucleoplasm and promotes its nucleolar localization, preventing cancer cells from senescence and maintaining cancer proliferation.246 Furthermore, Lee et al.247 showed that Ncl combines with astrocyte-elevated gene-1 in breast cancer to promote the growth and metastasis of breast cancer cells. The gene discussed is NUCLEOLIN; the disease is cancer.