MYC and cancer: Many studies have demonstrated that RPs regulate the expression of oncogenes and cancer suppressor genes and therefore participate in the development and metastasis of cancers.238 The oncogene Myc acts as an active hub for the progress of cancer239 and increases the rate of ribosome biogenesis by directly activating rRNA synthesis in cancer cells.39,240,241 Meanwhile, the direct binding of Myc to rDNA activates the synthesis of 47S pre-rRNA.