Mechanistically, Ncl improves cardiac function during MI by enhancing M2 macrophage polarization.169 In mouse models of MI, autophagy-related gene deletion or drug inhibition aggravates cardiac dysfunction and myocardial remodeling.170 Deng et al.166 found that the Ncl/autophagy signaling pathway is upregulated in the infarcted myocardium. Here, NUCLEOLIN is linked to myocardial infarction.