Crossing these mice with Eμ-Myc transgenic mice showed that c-Myc was upregulated and significantly accelerated the development of B-cell lymphomas.253,254 The ability of mutant MDM2 C305F to promote tumorigenesis in a c-Myc-driven cancer model is caused by the inability of the RPL5/RPL11/5S rRNA complex to upregulate p53 levels. The gene discussed is TP53; the disease is cancer.