Notably, the lysosomal inhibitor ammonium chloride (NH4CL) markedly abrogated the protein degradation of VILIP3 induced by desloratadine in HCC cells, suggesting that lysosomal degradation may account for the effect of desloratadine on VILIP3 (Fig. 5e). This evidence concerns the gene HPCAL1 and hepatocellular carcinoma.