Moreover, desloratadine markedly reduced the mRNA and protein expression of Bcl-2 (Fig. 5g, h), which is not only a critical downstream target of the NFκB pathway but is also closely related to the progression of HCC.21 Overexpression of p65 significantly reduced the inhibition of the proliferation, migration, and invasion by desloratadine in HCC cells (Fig. 5i, j and Supplementary Fig. 6c). This evidence concerns the gene NFKB1 and hepatocellular carcinoma.