Interestingly, the reduced sensitivity to desloratadine in the NMT1 knockdown HCC cells was significantly restored in the cells with re-overexpression of wild-type NMT1 or other mutants, but not in the cells with re-overexpression of the NMT1N246A mutant (Fig. 3h). The gene discussed is NMT1; the disease is hepatocellular carcinoma.