PDPN and cancer: On the one hand, cancer cells release several components, alone or within microvesicles, that are known to trigger a thrombo-inflammation state, including pro-clotting proteins (e.g., coagulation factors VII (FVII) and VIII (FVIII), cancer pro-coagulant, phosphatidylserine (PS), podoplanin (PDPN) and tissue factor (TF)), inflammatory cytokines (e.g., IL-6, which induces megakaryopoiesis), fibrinolytic regulators (e.g., plasminogen activator inhibitor-1 (PAI-1)) and pro-angiogenic factors (e.g., vascular endothelial growth factor (VEGF)) (Fig. 2).