TNF and rheumatoid arthritis: In a study from 11 registries from 9 European countries: France, Sweden, Czech, UK, Denmark, Italy, Germany and Portugal on 130,315 RA patients; for biologic naive patients the age at onset was 56.4 years and F:M 2.6:1 and for those who received anti-TNF the age at onset was 46.5 years and F:M was 3:1 [45].