The anti-lipidemic and anti-inflammatory activities of our OLECp, besides the other polyphenols, could be linked with the higher percentage of oleuropein and luteolin-7-O-glucoside, as also demonstrated by their anti-adipogenic effect due to the transcriptional inhibiting of PPARγ [58,106,107] and by the anti-inflammatory activity mediated by the inhibition of IL-1β and TNF-α production in an in vitro model of obesity-induced inflammation [108]. The gene discussed is IL1B; the disease is obesity due to melanocortin 4 receptor deficiency.