Additionally, since heat shock causes rapid translocation of IkappaB kinase (IKK) and nuclear factor kappa B (NF-κB) complexes into the plasma-membrane-associated lipid rafts and segregates the HSP90α cofactor from the IKK complex, it might contribute to the apoptotic loss of lymphocytes in sepsis-associated hyperthermia [49]. This evidence concerns the gene NFKB1 and Sepsis.