PNPLA2 and familial hypercholesterolemia: Consistent with previous reports [20,21,26,27,28], our findings showed that HFD-fed animals presented the typical features of hepatic steatosis and hyperlipidemia, including high serum FFA, hypertriglyceridemia, and hypercholesterolemia, associated with the elevated expression of ATGL in adipose tissue, CD36, LXRα, SREBP-1c, SREBP-2, and HMGCR, as well as decreased CPT1A expression in the liver, which were overall reversed by RRBE treatments, especially at the middle and high doses.