Using the HFD-induced NAFLD mice model, we demonstrate that RRBE can alleviate NAFLD and dyslipidemia by regulating the expression of lipid-regulatory genes, including FA/TG (↓ATGL, ↓CD36, ↑LPL, ↓LXRα, ↓SREBP-1c, and ↑CPT1A), cholesterol (↓SREBP-2 and HMGCR), and HDL (↓HL and ↑ApoA-ǀ) metabolic genes, in the liver and adipose tissues. This evidence concerns the gene HMGCR and metabolic dysfunction-associated steatotic liver disease.