Moreover, phenolic extract and hydrolyzed bound phenolics from rice bran, as well as other bioactive compounds such as proanthocyanidin, protocatechuic acid, oryzanol, vitamin E, and coenzyme Q10, modified the expression of key genes or proteins involved in hepatic lipid metabolism, such as CD36, LXRα, SREBP-1c, FA synthase, CPT1A, SREBP-2, and/or HMGCR, and led to the decrease in hepatosteatosis and hyperlipidemia in animal models with metabolic syndrome [14,29,32,33,34,35,36]. This evidence concerns the gene HMGCR and metabolic syndrome.