NR1H3 and Hyperinsulinemia: At the hepatocyte level, the activation of SREBP-1c by LXRα in response to hyperinsulinemia also primarily induces FA and TG synthesis by up-regulating lipogenic genes, such as FA synthase and acetyl-CoA carboxylase (ACC), whereas the activation of SREBP-2 primarily promotes cholesterol biosynthesis by up-regulating cholesterogenic genes, such as HMGCR, a rate-limiting enzyme of the cholesterogenic process [4,6].