In this regard, after confirming that perinatal MHF could cause an increase of AII-mediated pressor responses, we showed that the AT1R-PKCβ-LTCC signal pathway is involved in the vascular hyper-contractility in response to AII in the MHF offspring, adding new information to understand the pathological mechanisms of MHF-impaired vascular functions in relation to development. The gene discussed is PRKCB; the disease is Marburg hemorrhagic fever.