Additionally, Lee and Lee have found, that sanguiin H-6 has an antiproliferative effect on endothelial cells stimulated with vascular endothelial growth factor (VEGF) (IC50 ≈ 7.4 μg/mL) but does not affect the growth of HT1080 (human fibrosarcoma) cells [48]. This evidence concerns the gene VEGFA and fibrosarcoma.