Furthermore, resveratrol can influence the occurrence and progression of myocardial fibrosis by activating sirtuin 3 (SIRT3), regulating the levels of type I collagen gels (COL1), type III collagen gels (COL3) and hydroxyproline (Hyp), and the expression of TGF-β, or by regulating the levels of SDF-1 and immune cytokines such as TNF-α, malondialdehyde (MDA) and IL-1 in oxidative stress [61]. Here, TNF is linked to Myocardial fibrosis.