SIRT1 and Myocardial fibrosis: Particularly, resveratrol results in improving adriamycin-induced myocardial fibrosis by increasing SIRT1 and by decreasing factor β1 (TGFβ1), which lead to an increase of glutathione (GSH) and SOD and a decrease of MDA, Hyp, TNF-α and creatine kinase-MB (CK-MB).