Chronic kidney disease (CKD) is associated with multiple abnormalities that lead to a complex disorder comprising biochemical alterations in the metabolism of calcium, phosphorus, parathyroid hormone (PTH), Vitamin D, and fibroblast growth factor-23 (FGF-23), abnormalities in bone turnover, mineralization, volume, linear growth or strength, and vascular calcification leading to an increase in bone fractures and vascular disease, which ultimately result in high morbidity and mortality [1,2]. The gene discussed is FGF23; the disease is chronic kidney disease.