GSTM1 and silicosis: To further investigate the relationship between Nrf2 and GSH metabolism in silicosis, we used the GeneMANIA database (http://genemania.org/, accessed on 3 July 2021) to analyze the gene interaction network of Gstm1, Mgst1, and Nfe2l2 and found that these three genes form a gene–gene interaction network through Gstm2 (Figure 8A).