Among them, Gstm1, Gsto1, Gsta4, and Mgst1 jointly participate in the regulation of multiple signaling pathways with significant effects, including the metabolism of xenobiotics by cytochrome P450 (ko00980, p < 0.001), drug metabolism by cytochrome P450 (ko00982, p < 0.001), chemical carcinogenesis (ko05204, p < 0.001), glutathione metabolism (ko00480, p < 0.001), fluid shear stress and atherosclerosis (ko05418, p < 0.05). The gene discussed is GSTO1; the disease is atherosclerosis.