miR-34a can regulate liver steatosis by inhibiting very low-density lipoprotein secretion and by promoting hepatic oxidative stress and inflammation through different molecular structures such as hepatocyte nuclear factor 4, alpha (HNF4α), sirtuin1 (Sirt1), and cyclin-dependent kinase 6 (CDK6) [34,35,51]. The gene discussed is HNF4A; the disease is Hepatic steatosis.