For example, miR-589–3p is edited by ADAR2 in normal brain cortices compared to de novo glioblastoma, which changes the target gene of miR-34a from the protocadherin 9 (PCDH9) to the metalloprotease Metalloproteinase 12 (ADAM12) [18]. The gene discussed is PCDH9; the disease is glioblastoma.