CPT2 and hydrops fetalis: It has been observed that maternal HF diet downregulates mRNA and protein expressions of carnitine palmitoyltransferase 2 (CPT2), an enzyme with an important role in FAO, by suppressing the AMPK/Sirt1/PGC1α signaling pathway in the placenta; therefore, decreased FAO in the placenta was related to an increased placental weight and a fetal growth restriction due to an intracellular lipid accumulation [50,51,52,53].