Moreover, it was supposed that a maternal diet with a high GI may influence the expression of leptin (LEP) and fat mass and the obesity-associated gene (FTO), as well as other appetite-related genes, like agouti-related peptide (Agrp), neuropeptide Y (Npy), pro-opiomelanocortin cocaine (Pomc), amphetamine-regulated transcript (Cart) and leptin receptor (Lepr) in specific tissues [36]. The gene discussed is LEPR; the disease is obesity due to melanocortin 4 receptor deficiency.