It has been reported that the transcript levels of STAT3-regulated anti-apoptotic genes Bcl-2 and MCL-1 or proapoptotic gene such as caspase-3 were both upregulated in Chronic lymphocytic leukemia (CLL) cells from patients [44] and myeloid cells [45]. This evidence concerns the gene CASP3 and B-cell chronic lymphocytic leukemia.