A total of 68 articles were derived from 59 RCTs were included in NMAs and geometric framework for quantitative syntheses, including 56 for HDL cholesterol, 55 for triglycerides, 54 for LDL cholesterol, 53 for total cholesterol, 39 for glucose, 32 for insulin, 28 for hsCRP, 17 for apoB, 16 for apoA-1, 13 for Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), and 8 for IL-6. This evidence concerns the gene IL6 and Insulin resistance.