In contrast, its dysfunction may link to the adverse outcomes of obesity, including insulin resistance, type 2 diabetes, fatty liver disease, and chronic inflammation (TNF-α, IL-6-8-10, transformation growth factors β, interferon-γ, C-reactive protein/CRP, and fatty acid-binding protein4/FABP4) [60,63,64,65]. The gene discussed is CRP; the disease is Insulin resistance.