Elevated aggressive tumour marker of AMP and UDP-GluNAc was associated with up regulated transcript expression of clustering metabolic enzymes involving in glucose transport (GLUT1), mitochondria bioenergetics (PDHA), glutaminolysis (GLS), serine biosynthesis (PHGDH and PSPH), folate transport (PCFT and FOLR1), and folate cycle (SHMT1 and SHMT2) (Figure 5A). This evidence concerns the gene PDHA1 and neoplasm.