Higher expression of metabolic genes in glycolytic lactate and serine/folate cycle metabolism, such as GLUT1 (HR = 1.43, log-rank p = 3.3 × 10−8), GLUT4 (HR = 1.25, log-rank p = 0.00045), MCT1 (HR: 1.36, log-rank p = 1.9 × 10−6), MCT4 (HR = 1.5, log-rank p = 3.1 × 10−10), LDHA (HR: 1.63, log-rank p = 4 × 10−14), PHGDH (HR = 1.46, log-rank p = 3.4 × 10−9), PSAT1 (HR = 1.88, log-rank p = 1.1 × 10−13), and SHMT2 (HR = 1.51, log-rank p = 1.5 × 10−10), predicted poorer prognoses and lower diseases-free survival rates in LC patients. This evidence concerns the gene SHMT2 and laryngotracheoesophageal cleft.