CA2 and atopic eczema: A significant increase in mRNA expression was measured for atopic dermatitis-associated specific biomarkers such as neural EGFL-like 2 (NELL2), carbonic anhydrase 2 (CA2), and eotaxin-3 (CCL26) following co-incubation of cytokines and histamine (p < 0.05, p < 0.01, p < 0.001, respectively; Figure 2a), while treatment with histamine alone did not change the induction of NELL2, CA2 and CCL26 significantly.