FLG and atopic eczema: While prior investigations demonstrated that the atopic dermatitis skin models show skin barrier defects due to the loss of filaggrin (Figure 3a(I)), a pre-incubation with 5 μM α-13’-COOH increased filaggrin content in atopic dermatitis skin model m3 compared to the untreated disease controls in a manner comparable to dexamethasone (Figure 7c).