Moreover, histamine increased histamine 1 receptor (H1R; 3.6 ± 0.7-fold, p < 0.01; Figure 2a) and hyaluronic acid synthase 3 (HAS3; 3.6 ± 0.8-fold, p < 0.01; Figure 2a) expression under atopic dermatitis conditions compared to healthy controls. This evidence concerns the gene HAS3 and atopic eczema.