EWSR1 and histiocytoma, Angiomatoid fibrous: EWSR1 has recently been identified as a ‘hybrid’ gene implicated in several mesenchymal tumor translocations, with data indicating that it may be translocated and fused with a variety of partner genes, including EWSR1-FLI1 t(11;22) (q24;q12) and EWSR1-ERG in Ewing’s sarcoma [6], EWSR1-WT1 in desmoplastic small round cell tumors [7], EWSR1-CREB in angiomatoid fibrous histiocytoma [8], EWSR1-DDIT3 in myxoid liposarcoma [9], and EWSR1-ATF1 in clear-cell sarcoma-like tumors of the gastrointestinal tract [10].