EDN1 and stroke disorder: At 7 and 21 d after ET-1 injection, both the nondiabetic and diabetic mice with stroke showed a significant decrease in expressions of mature OLG markers, including myelin regulator 2‘,3‘-cyclic nucleotide 3‘-phosphohydrolase (CNpase) (Figure 4C,F and Figure 5) in the hippocampus and the cerebral cortex, myelin-associated glycoprotein (MAG) (Figure 4E,H), and myelin OLG protein (MOG) (Figure 4D,G) in the hippocampus.