Furthermore, the patients suffering from Addison’s disease which is primary known as adrenal insufficiency also suffer from hyperpigmented skin due to elevated levels of Adrenocorticotropic hormone (ACTH), a polypeptide tropic hormone produced and secreted by the anterior pituitary gland that stimulates adrenal glands to release cortisol [36]. The gene discussed is POMC; the disease is Adrenal insufficiency.