Furthermore, MMP3 is known as stromelysin-1, and plays an important role in joint and bone injury, and radiological erosion, as well as a biomarker reflect RA disease; matrix metalloproteinase (MMPs) was secreted when synovial fibroblasts were activated by pro-inflammatory cytokines such as TNF and IL-6. The gene discussed is TNF; the disease is rheumatoid arthritis.