AKT1 and atopic eczema: Besides, purpurin suppressed atopic dermatitis by TNF-α/IFN-γ-induced inflammation in HaCaT cells via inhibition of the activation of protein kinase B (AKT), mitogen-activated protein kinase (MAPKs), and nuclear factor kappa-light-chain-enhancer of activated B (NF-κB) [23].