These findings suggest that propranolol displays antiproliferative and antimetastatic properties, since it represses cell invasion, migration and angiogenesis through GC cell growth suppression by inhibiting β-adrenergic receptors, decreasing NF-κB levels and downregulating MMP-2/9, Cox-2 and VEGF gene expression [116,117]. Here, PTGS2 is linked to gastric cancer.