An investigation demonstrated that AGS, BGC-823, NCI-N87 and MKN28 GC cells display higher levels of HDAC2 than normal cells, indicating that GC leads to an overexpression of HDAC2, which is associated with poor prognosis [59], as well as the overexpression of HDAC1 [56]. The gene discussed is HDAC2; the disease is gastric cancer.