VEGFA and gastric cancer: It induces downregulation of nuclear factor kappa B (NF-κB) and proteins controlled by NF-κB, such as cyclin D1, COX-2, survivin, Bcl-xL, XIAP, ICAM-1, MMP-9 and VEGF, playing an important role in GC cells’ proliferation, angiogenesis and metastasis [69], since the transcription factors of the NF-κB family regulate several genes, which are involved in cell proliferation, apoptosis, morphogenesis and differentiation [206], and therefore promotes cell damage response and cell survival [112].