Nomilin pretreatment delayed the progression of osteoarthritis in mice, suppressed the IL-1β induced over-regulation of pro-inflammation factors NO, IL-6, PGE2, iNOS, TNF-α, and COX-2, and down-regulated the degradation of the extracellular matrix induced by NF-κB/IL-1β signaling via disassociation of Keap1-Nrf2 in chondrocytes [67]. Here, IL1B is linked to osteoarthritis.