In carbon tetrachloride-induced hepatic fibrosis mice, obacunone suppresses the TGF-β/Smad signals and epithelia mesenchymal transformations process, reduced levels of fibrosis markers α-SMA, collagen1, and vimentin, and exhibited an anti-oxidation effect by inhibiting reactive oxygen species via the activation of Nrf-2 and Glutathionperoxidase-4, a member of the glutathione peroxidase family alleviating oxidative stress, suggesting that obacunone could attenuate liver fibrosis via enhancing the Glutathionperoxidase-4 signal and inhibition of the TGF-β/Smad pathway [79]. The gene discussed is NFE2L2; the disease is Hepatic fibrosis.