Recent studies have confirmed that TFF1, but not TFF2 or TFF3, binds and colocalizes Piezo1 in the cytoplasm, suggesting that this interaction may be a therapeutic target for inhibiting the invasion and metastasis of gastric cancer, and that this interaction has a significant role in mediating the migration of cancer cells in the gastric cavity, which suggests that it may be an effective therapeutic target to inhibit the invasion of the gastric cavity, and the metastasis of the cancer [35]. This evidence concerns the gene TFF3 and cancer.