In addition, in doxorubicin-induced rat liver injury, Nar treatment was shown to have protective effects against hepatocyte necrosis, cholestasis, and membrane permeability, whilst also significantly reducing levels of the liver injury markers of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in mice [29]. The gene discussed is GPT; the disease is cholestasis.