TGFB1 and hepatocellular carcinoma: Correspondingly, the downregulation of immunosuppressive cells, such as M2-like TAMs, Tregs, and MDSCs, was also observed when HCC-bearing mice were administrated with the plumbagin and dihydrotanshinone I. Moreover, the plumbagin could increase IFN-γ, IL-12, and TNF-α and decrease IL-4, IL-10, and TGF-β [102].