Then, bufalin-induced upregulation of the M1-like TAMs stimulated the Th1 cell proliferation and Th1-associated anti-tumor cytokines (IL-2 and IFN-γ) accumulation, while decreasing the proportion of Th2 and its pro-tumor cytokines (IL-4 and IL-13) in the TME [111,170]. Here, IL2 is linked to neoplasm.