Moreover, they observed the highest miR-365 expression level in exosomes of IM-sensitive CML cells, and identified that exosomes mediated the transfer of miR-365 between IM resistant and sensitive CML cells, and that miR-365 induced DR by inhibiting expression of pro-apoptosis proteins BAX and Cleaved Caspase-3 in IM-sensitive CML cells [170]. This evidence concerns the gene CASP3 and chronic myelogenous leukemia, BCR-ABL1 positive.