Taking into account the above-mentioned activities of AKG and the fact that the expression of neutral endopeptidase implicated in the growth and metastasis of cancer cells is regulated epigenetically, we explored the potential effect of AKG on the expression of NEP in cells derived from cervical cancer, colon cancer, and osteosarcoma as well as normal epithelial cells of the intestine and osteoblasts. Here, MME is linked to cancer.