These preliminary results suggested that the effect of AKG on the NEP expression may have been dependent on whether cells have undergone neoplastic transformation (HOS vs. hFOB), the type of cancer (osteosarcoma vs. cervical and colon cancer), and finally the phenotype and/or stage of cancer (HOS vs. Saos-2). The gene discussed is MME; the disease is malignant colon neoplasm.