That is, when cellular iron levels are low, IRP rescues cellular iron deficiency by the following two mechanisms: (1) binding of IRP to the 5′UTR of mRNA blocks mRNA translation of key proteins associated with iron storage and export; (2) binding of IRP to the 3′UTR of mRNA elevates mRNA translation of key proteins related to iron uptake. The gene discussed is WNT2; the disease is Iron deficiency anemia.