TNF and juvenile idiopathic arthritis: With regard to JPsA outcome, an analysis of 336 JIA patients, 31 of whom had JPsA, evaluated by Flatø and colleagues after a median disease duration of 23 years, showed that JPsA was associated with an unfavorable outcome compared to the other JIA categories in terms of physical health self-assessment and need for disease-modifying anti-rheumatic drugs and/or anti-tumor necrosis factor agents [36].