We found that (1) common myeloid progenitors reside in the livers of juvenile mice even after the main site of hematopoiesis has transitioned to the BM, (2) PLI leads to the expansion of common myeloid progenitors in neonatal mouse liver and causes an expansion of mature myeloid progenitors in juvenile mouse liver, and (3) targeted depletion of HSPCs using anti-CD117 and anti-CD47 prevents the development of RRV-induced PLI, as demonstrated by improved survival, increased jaundice clearance, and decreased liver injury. The gene discussed is CD47; the disease is Jaundice.