Using the Youden index, the optimal cut-off values of age, BMI, ICG-R15, EHBF, PLT, ALB, HGB, ALT, AST, TBIL, DBIL, PT, APTT, INR, tumor size, operation time, blood loss, and HIO time were determined to be 50.5 years, 25.523 kg/m2, 2.850%, 0.902 L/min, 167.5 × 109/L, 42.15 mg/dL, 15.05 g/dL, 38.35 U/L, 31.350 U/L, 6.85 μmol/L, 3.55 μmol/L, 12.050 s, 27.250 s, 1.045, 65.5 mm, 88.5 min, 275 mL, and 21.3 min, respectively. The gene discussed is CYGB; the disease is neoplasm.