In addition, early growth response 1 (EGR1) and regulator of G-protein signaling 2 (RGS2), the target genes of hsa-miR-191-5p, are mainly involved in the gonadotropin-releasing hormone (GnRH) signaling pathway, apelin signaling pathway, oxytocin signaling pathway and cGMP-PKG signaling pathway (Table A2), which are interrelated to BC [59]. This evidence concerns the gene APLN and breast cancer.