IL10 and acute respiratory distress syndrome: Indeed, in mice with cigarette smoke-induced ALI, the administration of resolving (Rv)D1, concurrently with cigarette smoke exposure, significantly reduced neutrophilic lung inflammation and production of pro-inflammatory cytokines (Table 4), while increasing the anti-inflammatory cytokine IL-10 and promoted differentiation of M2 macrophages and neutrophil efferocytosis.