In 2008, Hartel et al. reported that enhanced alternative splicing of the KLF6 gene positively correlates with better prognosis in patients with pancreatic cancer samples, and the increased alternative splicing of KLF6 was primarily due to enhanced splice form expression rather than reduced KLF6 full length mRNA, indicating alternative splicing of KLF6 as a growth-promoting mechanism in human cancer. Here, KLF6 is linked to cancer.