TTF1 and laryngotracheoesophageal cleft: To confirm whether the results in this study were influenced by including the subpopulation of nonadenocarcinoma, such as NOS and LC-NEC, in both patients who were TTF-1-positive and those who were TTF-1-negative, we performed an additional survival analysis on the histologic subtype of adenocarcinoma alone, but the obtained results were very similar to those presented herein, which leads us to believe that TTF-1 could be a prognostic factor (Supplementary Figure S3A,B).