SASP, senescence-associated secretory phenotype, refers to several highly secreted cytokines (e.g., IL-1, IL-6, IL-13, IL-15), chemokines (e.g., CXCL1, CXCL8, CXCL12, ENA-78), growth factors (e.g., EGF, FGF, HGF, TGF-β, VEGF, angiogenin, epiregulin), extracellular matrix (ECM) proteins and remodeling enzymes (e.g., MMP-1, -3, -10), soluble receptors and ligands (e.g., ICAM-1, EGF-R, Fas) and other elements that promote cancer proliferation and metastases [27]. The gene discussed is EGFR; the disease is cancer.