As shown in Table 5, the univariate Cox analysis demonstrated that the diabetes duration (p = 0.042), e-GFR (p < 0.001), albumin (p < 0.001), Hb (p < 0.001), proteinuria (p = 0.006), use of ACEI/ARB (p = 0.001), use of Insulin (p = 0.004), glomerular damage (p < 0.001), IFTA lesions (p = 0.002), and interstitial inflammation (p < 0.001) were associated with a higher risk for renal dysfunction. This evidence concerns the gene INS and diabetes mellitus.