GLP1R and polycystic ovary syndrome: This review focusses on non-hormonal treatment options for menstrual irregularities in adolescents with PCOS including MET, Glucagon-like peptide 1 receptor agonists, thiazolidinediones (rosiglitazone, pioglitazone), anti-androgen agents (spironolactone, finasteride, flutamide), combination treatment with SPIOMET and supplements (chromium picolinate, myo-inositol).