TIMP2 and acute kidney injury: What is more, the urinary biomarkers tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin growth factor-binding protein 7 (IGFBP7) have been approved to help in identifying patients at a high risk for AKI in some interventional studies in cardiac and visceral surgery settings [52,53,54], as well as for improving the prediction levels of RRT and 30-day mortality after cardiac surgery [55].