The main clinical predictors of fg-SRL resistance recognized in the literature include: male sex [5,13,14], young age [5,13,14,15,16,17] and tumor hyperintensity on T2-weighted magnetic resonance imaging (MRI) scans [1,7,13,15,16]; however, IGF-I and r-GH values at diagnosis also deserve to be taken into consideration [5,8,13,14,15,16,17]. The gene discussed is GH1; the disease is neoplasm.