A logistic regression analysis was performed next, considering the disease phenotype (CIS, RRMS, and PPMS) or the condition of HC as the dependent variable, and MBP concentrations in ODEVs, as well as gender, age, and presence of at least one HLA-DRB1*15 allele as covariates. The gene discussed is HLA-DRB1; the disease is in situ carcinoma.