GPC1 and pancreatic intraductal papillary-mucinous neoplasm: Melo et al. observed that GPC1+ EVs were also significantly higher in patients with histologically proven IPMN (n = 5) undergoing surgery because of clinical symptoms or evidence of a macroscopic mass in comparison with healthy donors and a benign pancreatic disease control group (18 patients with pancreatitis and 8 with serous cystic adenomas).