Finally, in a Cox regression model which included the decrease in GPC1+ exosomes levels, median age, American Joint Committee on Cancer (AJCC) stage, tumor grade, and CA 19-9 levels, only GPC1+ exosomes level was an independent prognostic and predictive marker for disease-specific survival (hazard ratio (HR): 5.353, CI: 1.651–17.358, p = 0.005) [56]. This evidence concerns the gene GPC1 and neoplasm.