GPC1 and neoplasm: Indeed, Frampton and colleagues confirmed the correlation between GPC1+ EVs levels and tumor burden: patients with higher GPC1+ EVs levels had significantly larger PDAC (>4 cm; p = 0.012) and in matched pre- and post-operative plasma samples there was a significant reduction of GPC1 levels after surgical resection for PDAC (97 ± 54 vs. 77.8 ± 32.4 pg/mL; p = 0.0428).