In B-cell chronic lymphocytic leukemia, B-cell glycosylation is altered in a way that allows interaction with galectin 1, thereby lowering the B cell receptor (BCR) signaling threshold; this causes the signaling and survival of these B cells; in addition, the interaction of galectin 1 with glycans stimulates the expression of BAFF and APRIL that promote cell survival [48]. Here, LGALS1 is linked to B-cell chronic lymphocytic leukemia.