T2-low asthma patients are characterized by sputum neutrophilia secondary to the activation of the NLRP3 inflammasome and elevated IL-1β; the activation of Th1 and/or Th17 cells associated with the imbalance of Th17/Treg cells seems to play an essential role in the pathology of asthma [44]. This evidence concerns the gene NLRP3 and asthma.