García-Valero et al. found the decreased expression of extracellular SOD in the alveolar, bronchial, and arteriolar walls of COPD patients compared with the control group (0.59 ± 0.64 vs. 1.39 ± 0.63, respectively; p < 0.05). The gene discussed is SOD1; the disease is chronic obstructive pulmonary disease.